Schering Laboratories, Kenilworth, NJ. Applies to: Glaucoma/Intraocular Hypertension. "Product Information. (1992): 880, Shutt LE, Bowes JB "Atropine and hyoscine." Relieves spasms or cramping and controls excessive bronchial, pharyngeal, stomach, and tracheal secretions. Phenergan (promethazine)." (1986): 75-86. Mevorach D "Adverse effects of atropine sulfate autoinjection." Take with food. Anesthesiology 39 others, such as amantadine, belladonna-containing medicines, macimorelin, or potassium supplements. "Product Information. Anaesthesia 34 Because antimuscarinic agents have anticholinergic effects, they are contraindicated in patients with myasthenia gravis. Moderate Potential Hazard, Low plausibility. There are 19 disease interactions with hyoscyamine: Major Potential Hazard, High plausibility. Wyeth-Ayerst Laboratories, Philadelphia, PA. "Product Information. Kidney disease does not tend to cause symptoms when it's at an early stage. We comply with the HONcode standard for trustworthy health information -, Drug class: anticholinergics/antispasmodics. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Moderate Potential Hazard, Moderate plausibility. May not be suitable for seniors over the age of 65 years. (1976): 1186-90, Howells TH "The administration of metoclopramide with atropine." Glaxo Wellcome, Research Triangle Park, NC. Anaesthesia 32 Minor Potential Hazard, Moderate plausibility. Use the medicine exactly as directed. Hyoscyamine is used to treat a variety of stomach/intestinal problems such as cramps and irritable bowel syndrome. In addition to theses, this medicine is considered good for Parkinson’s disease. Curr Med Res Opin 5 Only traces of this drug are found in breast milk. Applies to: Fever. Dimetane (brompheniramine)." liver or kidney disease; heart problems; or; breathing problems. Obstet Gynecol 51 This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Antimuscarinic agents may further aggravate the diarrhea. "Product Information. Levsin SL (Hyoscyamine Sulfate) works by decreasing acid production in the stomach. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. (1973): 635, Das G, Talmers FN, Weissler AM "New observations on the effects of atropine on the sinoatrial and atrioventricular nodes in man." Applies to: Bleeding. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Separate administration (take hyoscyamine an hour before or two hours after antacids). Available in many different dosage forms (for example, an oral tablet, disintegrating tablet, sublingual tablet, liquid, and extended-release tablet or liquid). Acetylcholine is a neurotransmitter. Talk to your doctor about decreasing your dosage if you experience an excessively dry mouth. Hyoscyamine and phenyltoloxamine is a combination medicine that is used to treat indigestion (upset stomach, gas, bloating), and to reduce stomach acid. May cause drowsiness and affect your ability to drive or operate machinery. Do not drive until you know how hyoscyamine affects you. Hyoscyamine in Irritable Bowel Syndrome (IBS) Irritable Bowel Syndrome or IBS is a persistent disease of the large intestine. Compazine (prochlorperazine)." However, ipratropium does not produce these effects and can be used safely in treating asthma. Acta Med Scand 199 (1974): 327-32, Lazzari JO, Benchuga EG, Elizari MV, Rosenbaum MB "Ventricular fibrillation after intravenous atropine in a patient with atrioventricular block." Major Potential Hazard, High plausibility. Antimuscarinics (Includes hyoscyamine) ↔ coronary artery disease. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. Occasionally, may be considered for certain heart conditions or to help control the symptoms of Parkinson's disease. Applies to: Arrhythmias, Ischemic Heart Disease. It is by slowing down the natural … "Product Information. These drugs should be administered cautiously to patients with ulcerative colitis. (1982): 196-200, Massumi RA, Mason DT, Amsterdam EA, DeMaria A, Miller RR, Scheinman MM, Zelis R "Ventricular fibrillation and tachycardia after intravenous atropine for treatment of bradycardias." Acetylcholine is a … J Allergy Clin Immunol 70 Bock Pharmaceutical Company, St. Louis, MO. (1985): 558-60. J Antimicrob Chemother 9 (1982): 209-16 Australian Drug Evaluation Committee "Adverse effects of drugs … Am J Ophthalmol 99 Atropine-like agents are primarily eliminated by the kidney. See your doctor urgently if you develop agitation, ataxia (the loss of full control of body movements), confusion, disorientation, eye pain, hallucinations, short-term memory loss, or speech difficulties while taking hyoscyamine. Moderate Potential Hazard, Moderate plausibility. Cardiovascular effects of anticholinergics may exacerbate hypertension. Applies to: Diarrhea. May be considered in children over the age of six with urinary incontinence to help control urination. It's a common condition often associated with getting older. ESI Lederle Generics, Philadelphia, PA. "Product Information. "Product Information. Dysuria may occur and may require catheterization. Marezine (cyclizine)." Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It decreases the motility of the gastrointestinal (GI) tract and reduces the secretion of acid from the stomach and other fluids from the gastrointestinal tract and airways. 1  Levsin (which also goes by the brand name Anaspaz) is prescribed by a physician to relax the muscles in the bladder and … Hyoscyamine sulfate Injection, USP inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. In general, the use of anticholinergic agents is contraindicated in patients with urinary retention and bladder neck obstruction caused by prostatic hypertrophy. Minor Potential Hazard, Low plausibility. Chronic kidney disease (CKD) is a long-term condition where the kidneys don't work as well as they should. 14th ed." Speak to your doctor about how drug interactions should be managed. Cogentin (benztropine)." "Product Information. May be used as a premedication before anesthesia, endoscopy, or some imaging studies. Int Ophthalmol Clin 11 "Product Information. (1971): 13-34. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with anticholinergics is rare. Premature ventricular depolarization, ventricular tachycardia, and fibrillation associated with anticholinergics are rare. Major Potential Hazard, Moderate plausibility. (1982): 458-64. J Clin Psychiatry 47 Agents with anticholinergic activity can exacerbate many of the manifestations of autonomic neuropathy, including tachycardia, anhidrosis, bladder atony, obstipation, dry mouth and eyes, cycloplegia and blurring of vision, and sexual impotence in males. Hyoscyamine sulfate is partly hydrolyzed to tropic acid and tropine but the majority of the drug is excreted in the urine unchanged within the first 12 hours. Simons FE, Frith EM, Simons KJ "The pharmacokinetics and antihistaminic effects of brompheniramine." Anticholinergics work by blocking the action of acetylcholine in the brain and at nerves throughout the body. Therapy with atropine-like agents should be administered cautiously to patients with renal disease. Hyoscyamine is also used as a drying agent to control excessive salivation, runny nose, or excessive sweating. (1990): 582. Hyoscyamine is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease. Hyoscyamine may also be used to treat rhinitis. Can Anaesth Soc J 24 Proc Soc Exp Biol Med 139 It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones. Brown JW "Toxic megacolon associated with loperamide therapy." May not be suitable for some people including those with heart or lung disease, liver or kidney disease, myasthenia gravis, prostate or thyroid problems, ulcerative colitis or an intestinal obstruction. Wyeth-Ayerst Laboratories, Philadelphia, PA. Pecora JL "Malignant glaucoma worsened by miotics in a postoperative angle- closure glaucoma patient." Therapy with antimuscarinic agents should be administered cautiously to patients with gastric ulcer. Available for Android and iOS devices. "Product Information. Major Potential Hazard, High plausibility. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare. Therapy with antimuscarinic agents and higher dosages of antispasmodic agents (e.g., dicyclomine or oxybutynin) should be administered cautiously in patients with autonomic neuropathy. A drug interaction effect on the gastro-oesophageal sphincter in man." There are 201 drug interactions with hyoscyamine, There are 2 alcohol/food interactions with hyoscyamine. JAMA 223 It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones, and Parkinson's disease. For non-prescription products, read the label or package ingredients carefully. (1978): 581-6, Cotton BR, Smith G "Single and combined effects of atropine and metoclopramide on the lower oesophageal sphincter pressure." Moderate Potential Hazard, Moderate plausibility. (1979): 225-8, Richman S "Adverse effect of atropine during myocardial infarction. These drugs should be administered cautiously in patients with gastroesophageal reflux or hiatal hernia associated with reflux esophagitis. Pfizer US Pharmaceuticals, New York, NY. JAMA 228 Med Lett Drugs Ther 17 Because anticholinergics cause mydriasis, they may exacerbate these conditions. 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